Polycomb-mediated chromatin compaction weathers the STORM
نویسندگان
چکیده
منابع مشابه
Argentina Weathers the Storm
The events of December 2001 seemed to transform Argentina’s international status from poster child to basket case. Throughout the 1990s, Argentina had been widely hailed as a case of successful market reform under democratic government. The radical economic transformation undertaken by the government of Carlos Saúl Menem had ended hyperinflation and restored economic growth, while the country e...
متن کاملChromatin compaction by a polycomb group protein complex.
Polycomb group proteins preserve body patterning through development by maintaining transcriptional silencing of homeotic genes. A long-standing hypothesis is that silencing involves creating chromatin structure that is repressive to gene transcription. We demonstrate by electron microscopy that core components of Polycomb Repressive Complex 1 induce compaction of defined nucleosomal arrays. Co...
متن کاملPolycomb "polypacks" the chromatin.
For decades, researchers have made a tremendous effort to characterize the chromosome organization in the nucleus. With the development of chromosome conformation capture (1) and related techniques, researchers have begun to gain insight at the molecular level into how interand intrachromosome contacts are formed. Quantitative measurement of the contact frequencies in metazoans suggested the ex...
متن کاملHistone acetylation and the maintenance of chromatin compaction by Polycomb repressive complexes.
Mechanisms controlling higher-order chromatin structure or chromatin compaction and linking this to gene regulation are poorly understood. Previously, we had shown that the PRC1 Polycomb repressive complex is required to maintain a compact chromatin state at Polycomb target loci in embryonic stem cells (ESCs) of the mouse and that this activity, together with the ability to repress target gene ...
متن کاملCompaction of chromatin by diverse Polycomb group proteins requires localized regions of high charge.
Polycomb group (PcG) proteins are required for the epigenetic maintenance of developmental genes in a silent state. Proteins in the Polycomb-repressive complex 1 (PRC1) class of the PcG are conserved from flies to humans and inhibit transcription. One hypothesis for PRC1 mechanism is that it compacts chromatin, based in part on electron microscopy experiments demonstrating that Drosophila PRC1 ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Genome Biology
سال: 2016
ISSN: 1474-760X
DOI: 10.1186/s13059-016-0899-y